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ea0029oc10.4 | Pituitary Clinical 2 | ICEECE2012

Higher glucocorticoid supplementation doses are associated with increased overall mortality in patients with non-functioning pituitary adenoma

Zueger T. , Kirchner P. , Herren C. , Allemann S. , Fischli S. , Zwahlen M. , Christ E. , Stettler C.

Introduction: Current treatment guidelines for patients with insufficiency of the hypothalamic pituitary adrenal (HPA) axis recommend weight adjusted glucocorticoid supplementation doses to minimize risk of negative side effects (e.g. osteoporosis etc).However, little is known on a potential dose-dependent effect of glucocorticoid supplementation on overall mortality in patients with pituitary disease. Non-functioning pituitary adenoma (NFPA) is one of t...

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ea0026p134 | Growth factors | ECE2011

Circulating insulin-like growth factor 1 (IGF1) and mortality: meta-analysis and dose-response meta-regression

Burgers A M G , Biermasz N R , Schoones J W , Pereira A M , Renehan A G , Zwahlen M , Egger M , Dekkers O M

Background: Insulin-like growth factor 1 (IGF1) plays a central role in metabolism and growth regulation. High IGF1 levels are associated with an increased risk of cancer, low IGF1 levels with increased risk for cardiovascular disease. We hypothesized that the relationship between circulating total IGF1 levels and mortality is U-shaped.Methods: We performed a systematic review searching PubMed, EMBASE, Web of Science, Cochrane Library (1985 to September ...

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Endocrine Abstracts

Higher glucocorticoid supplementation doses are associated with increased overall mortality in patients with non-functioning pituitary adenoma

Circulating insulin-like growth factor 1 (IGF1) and mortality: meta-analysis and dose-response meta-regression

BiosciAbstracts